Abstract
A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chromatography, Thin Layer
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HeLa Cells / drug effects
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Humans
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Japan
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Nuclear Magnetic Resonance, Biomolecular
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry*
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Secosteroids
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Solanaceae / chemistry*
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Spectrophotometry, Infrared
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Steroids / chemistry
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Steroids / isolation & purification*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Secosteroids
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Steroids
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physalin D
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physalin T