Abstract
Pegvisomant is a recombinant protein, structurally similar to natural human growth hormone (GH), which is capable of binding to the GH receptor as a competitive antagonist. As well as being evaluated for the treatment of acromegaly, pegvisomant is being investigated as a possible antineoplastic agent, initially in mice. So far, in vitro efficacy against meningioma and in vivo efficacy against colon and breast cancer cell lines have been examined.
MeSH terms
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Animals
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Breast Neoplasms / metabolism
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Human Growth Hormone / analogs & derivatives
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Human Growth Hormone / metabolism
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Human Growth Hormone / pharmacology*
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Humans
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Insulin-Like Growth Factor I / metabolism
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Meningioma / drug therapy
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Mice
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Neoplasms / drug therapy*
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Receptors, Somatotropin / antagonists & inhibitors*
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Tumor Cells, Cultured
Substances
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Receptors, Somatotropin
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Human Growth Hormone
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Insulin-Like Growth Factor I
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pegvisomant