Moderated multiple regression (MMR) arguably is the most popular statistical technique for investigating regression slope differences (interactions) across groups (e.g., aptitude-treatment interactions in training and differential test score-job performance prediction in selection testing). However, heterogeneous error variances can greatly bias the typical MMR analysis, and the conditions that cause heterogeneity are not uncommon. Statistical corrections that have been developed require special calculations and are not conducive to follow-up analyses that describe an interaction effect in depth. A weighted least squares (WLS) approach is recommended for 2-group studies. For 2-group studies, WLS is statistically accurate, is readily executed through popular software packages (e.g., SAS Institute, 1999; SPSS, 1999), and allows follow-up tests.