Abstract
Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.
MeSH terms
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Animals
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Cell Membrane / enzymology*
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Drosophila / cytology
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Drosophila / enzymology
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Drosophila / metabolism
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism
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Epidermal Growth Factor*
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Golgi Apparatus / enzymology
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Golgi Apparatus / metabolism
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Protein Processing, Post-Translational*
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Protein Structure, Tertiary
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Serine Endopeptidases / genetics
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Serine Endopeptidases / metabolism*
Substances
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Drosophila Proteins
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Membrane Proteins
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Rho protein, Drosophila
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Stet protein, Drosophila
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spi protein, Drosophila
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Epidermal Growth Factor
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Serine Endopeptidases