Cutting edge: induction of follicular homing precedes effector Th cell development

J Immunol. 2001 Dec 1;167(11):6082-6. doi: 10.4049/jimmunol.167.11.6082.

Abstract

Transition from naive to Ag-experienced effector/memory CD4+ T cells is initiated during contact with APC in secondary lymphoid tissue. Here, we demonstrate that the CXCR5 is a marker for recently activated memory CD4+ T cells. CXCR5 is rapidly induced during contact with Ag-presenting dendritic cells, well before T cell expansion and effector cell development, and is irreversibly lost on terminally differentiated effector cells. Furthermore, immunization of human volunteers with a recall Ag results in rapid accumulation of Ag-responsive, CXCR5-expressing CD4+ T cells in peripheral blood. Early acquisition of a new migration program enables T zone CD4+ T cells to develop into follicular B helper T cells or, alternatively, into circulating memory CD4+ T cells. Together, CXCR5 unequivocally defines pre-effector memory CD4+ T cells generated during ongoing immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Cell Differentiation / immunology
  • Cell Movement / immunology*
  • Cells, Cultured
  • Chemokines, CXC / metabolism*
  • Humans
  • Immunization
  • Immunologic Memory
  • Interphase / immunology
  • Lymphocyte Activation
  • Receptors, CXCR5
  • Receptors, Chemokine
  • Receptors, Cytokine / biosynthesis*
  • Receptors, Cytokine / blood
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocytes, Helper-Inducer / cytology*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism
  • Tetanus Toxoid / immunology

Substances

  • CXCR5 protein, human
  • Chemokines, CXC
  • Receptors, CXCR5
  • Receptors, Chemokine
  • Receptors, Cytokine
  • Tetanus Toxoid