[Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology]

Arzneimittelforschung. 1975 Jan;25(1):82-9.
[Article in German]
No abstract available

MeSH terms

  • Alanine Transaminase / blood
  • Alcohol Oxidoreductases / blood
  • Amanitins / antagonists & inhibitors
  • Anesthetics, Local / pharmacology
  • Animals
  • Aspartate Aminotransferases / blood
  • Body Temperature / drug effects
  • Carbon Tetrachloride Poisoning / drug therapy
  • Chemical and Drug Induced Liver Injury / drug therapy*
  • Dogs
  • Female
  • Flavonoids / therapeutic use*
  • L-Lactate Dehydrogenase / blood
  • Lethal Dose 50
  • Male
  • Mice
  • Phalloidine / antagonists & inhibitors
  • Rabbits
  • Rats
  • Silymarin / pharmacology
  • Silymarin / therapeutic use*
  • Silymarin / toxicity
  • Sorbitol
  • Time Factors
  • Vascular Resistance / drug effects

Substances

  • Amanitins
  • Anesthetics, Local
  • Flavonoids
  • Silymarin
  • Phalloidine
  • Sorbitol
  • Alcohol Oxidoreductases
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase