Injectable fluid silicone therapy. Human morbidity and mortality

JAMA. 1975 Oct 20;234(3):308-9.

Abstract

Four patients who had received silicone injections had the following complications: migration, hepatic disease manifested as granulomatous hepatitis (previously undescribed, to our knowledge), hypopigmentation, and death. Silicone should now be considered as a possible cause of hepatic granulomas in an appropriate host.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autopsy
  • Female
  • Granuloma / chemically induced
  • Humans
  • Injections / adverse effects
  • Liver / drug effects
  • Male
  • Pigmentation Disorders / chemically induced
  • Pulmonary Edema / chemically induced
  • Pulmonary Edema / pathology
  • Silicones / adverse effects*
  • Simethicone / administration & dosage
  • Simethicone / adverse effects*
  • Simethicone / therapeutic use
  • Skin / drug effects
  • Surgery, Plastic

Substances

  • Silicones
  • Simethicone