Abstract
Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Animals
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Bronchial Neoplasms / chemically induced
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Cystadenoma / chemically induced
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Dust
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Environmental Exposure
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Female
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Intubation, Intratracheal
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Lung / ultrastructure
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Lung Diseases / chemically induced*
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Lung Neoplasms / chemically induced
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Lymphocytes / drug effects
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Macrophages / drug effects
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Male
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Particle Size
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Polyurethanes / administration & dosage
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Polyurethanes / toxicity*
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Pulmonary Emphysema / chemically induced
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Pulmonary Fibrosis / chemically induced
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Rats