Abstract
The anti-stress and anti-fatigue effects on rats and mice of a hot water extract of rice bran fermented with Saccharomyces cerevisae IFO 2346 were investigated. Oral administration (1 g/kg/day) of the hot water extract of fermented rice bran (FRB) inhibited major changes in the weight of the adrenal, thymus, spleen and thyroid, showing an anti-stress effect. The hot water extract of FRB also inhibited increases in the GPT and LDH activity, cholesterol and glucose in the serum. The administration (1 g/kg/day) for 2 weeks significantly prolonged the swimming time, resulting in an increase in the anti-fatigue effect. It is considered from these results that FRB had anti-stress and anti-fatigue effects.
MeSH terms
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Adjuvants, Immunologic / metabolism
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Adjuvants, Immunologic / pharmacology
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Alkyl and Aryl Transferases / blood
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Animals
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Anthraquinones / blood
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Blood Glucose / metabolism
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Cholesterol / blood
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Disaccharides / blood
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Fatigue / prevention & control*
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Glucans / metabolism
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Glucans / pharmacology*
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L-Lactate Dehydrogenase / blood
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Male
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Mice
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Mice, Inbred ICR
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Organ Size
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Rats
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Rats, Sprague-Dawley
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Stress, Physiological / prevention & control*
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Swimming
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Transferases (Other Substituted Phosphate Groups) / blood
Substances
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Adjuvants, Immunologic
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Anthraquinones
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Blood Glucose
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Disaccharides
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Glucans
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rice bran saccharide
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ruberythric acid
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Cholesterol
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L-Lactate Dehydrogenase
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Alkyl and Aryl Transferases
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geranylpyrophosphate olivetolate geranyltransferase
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Transferases (Other Substituted Phosphate Groups)
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UDP-GlcNAc-undecaprenyl phosphate N-acetylglucosaminyl 1-phosphate transferase