Hemoglobin adducts in rats chronically exposed to room-aged cigarette sidestream smoke and diesel engine exhaust

R Stabbert; G Schepers; W S Stinn; H J Haussmann

doi:10.1007/978-1-4615-0667-6_20

Hemoglobin adducts in rats chronically exposed to room-aged cigarette sidestream smoke and diesel engine exhaust

Adv Exp Med Biol. 2001:500:153-6. doi: 10.1007/978-1-4615-0667-6_20.

Authors

R Stabbert¹, G Schepers, W S Stinn, H J Haussmann

Affiliation

¹ INBIFO Institut für biologische Forschung, Cologne, Germany.

PMID: 11764929
DOI: 10.1007/978-1-4615-0667-6_20

Abstract

Under controlled conditions with exaggerated concentrations of environmental aerosols, the biologically effective dose markers suggested in the literature as being specific for ETS (i.e., HPB Hb adducts for TSNA exposure) and DEE (i.e., l-aminopyrene Hb adducts for l-nitropyrene exposure) did not respond. A slight but dose-dependent increase in 4-ABP Hb adduct levels was seen in RASS-exposed rats.

MeSH terms

Animals
Automobiles
Female
Gasoline / adverse effects*
Hemoglobins / metabolism*
Male
Protein Denaturation*
Rats
Rats, Wistar
Tobacco Smoke Pollution / adverse effects*
Vehicle Emissions

Substances

Gasoline
Hemoglobins
Tobacco Smoke Pollution
Vehicle Emissions