Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

Yoshio Momose; Miho Murata; Kazuhiro Kobayashi; Masaji Tachikawa; Yuko Nakabayashi; Ichiro Kanazawa; Tatsushi Toda

doi:10.1002/ana.10079

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

Ann Neurol. 2002 Jan;51(1):133-6. doi: 10.1002/ana.10079.

Authors

Yoshio Momose¹, Miho Murata, Kazuhiro Kobayashi, Masaji Tachikawa, Yuko Nakabayashi, Ichiro Kanazawa, Tatsushi Toda

Affiliation

¹ Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan.

PMID: 11782995
DOI: 10.1002/ana.10079

Abstract

We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Brain-Derived Neurotrophic Factor / genetics*
Cytochrome P-450 Enzyme System / genetics
Dopamine / genetics
Female
Genetic Predisposition to Disease
Homozygote
Humans
Male
Middle Aged
Parkinson Disease / genetics*
Polymorphism, Single Nucleotide / genetics*
Thiolester Hydrolases / genetics
Ubiquitin Thiolesterase

Substances

Brain-Derived Neurotrophic Factor
Cytochrome P-450 Enzyme System
Thiolester Hydrolases
Ubiquitin Thiolesterase
Dopamine