Abstract
A thorough review of the clinical trial data combined with new in vitro experimental information may make the optimization of dosages of TB drugs possible. Several factors can affect the selection and dosage of TB drugs including hepatic and renal impairment, pregnancy, duration of disease before treatment, and extent of debilitation. Drug interactions and pharmacodynamics must be considered, and their roles are discussed.
MeSH terms
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Animals
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / pharmacokinetics
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Antitubercular Agents / pharmacology*
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Drug Monitoring
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Humans
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Kidney Diseases / complications
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Kidney Diseases / metabolism
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Liver Diseases / complications
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Liver Diseases / metabolism
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Mycobacterium tuberculosis / drug effects
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Tuberculosis, Multidrug-Resistant / complications
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Tuberculosis, Multidrug-Resistant / drug therapy*
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Tuberculosis, Multidrug-Resistant / microbiology