Abstract
We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin's lymphoma, and assessed the relationship of these proteins to clinical outcome and response to chemotherapy. Our results showed that p53 expression was an independent immunohistochemical parameter related to a poor prognosis in these lymphomas. Bcl-2, Bax, Bak and Mcl-1 proteins, though highly expressed in almost all cases were not associated with prognosis or response to treatment.
Copyright 2002 S. Karger AG, Basel
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Apoptosis* / genetics*
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Biomarkers / analysis
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Female
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Humans
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Immunohistochemistry
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Lymphoma, B-Cell / chemistry
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Lymphoma, B-Cell / mortality
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Lymphoma, B-Cell / pathology
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Lymphoma, Large B-Cell, Diffuse / chemistry
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Lymphoma, Large B-Cell, Diffuse / mortality*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Male
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Membrane Proteins / metabolism
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Middle Aged
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins / metabolism*
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Prognosis
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Retrospective Studies
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Survival Analysis
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Treatment Outcome
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Tumor Suppressor Protein p53 / metabolism
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bcl-2 Homologous Antagonist-Killer Protein
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bcl-2-Associated X Protein
Substances
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BAK1 protein, human
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BAX protein, human
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Biomarkers
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Membrane Proteins
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53
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bcl-2 Homologous Antagonist-Killer Protein
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bcl-2-Associated X Protein