Determination of iodine values according to Hanus using 1,3-dibromo-5,5-dimethylhydantoin (DBH): analytical methods of pharmacopeias with DBH: part 7

J Pharm Biomed Anal. 2002 Apr 1;28(1):81-6. doi: 10.1016/s0731-7085(01)00632-x.

Abstract

USP/NF 2000 [The United States Pharmacopeia, Rockville USA, 24th ed., 2000, p. 1868, The National Formulary, 19th ed. 2000] and PH. EUR. 1997 [European Pharmacopoeia, third ed., Council of Europe, Strasbourg, 1997, pp. 63-64] determine the iodine values according to Hanus with iodine monobromide in glacial acetic acid. This reagent can be replaced by a solution of 1,3-dibromo-5,5-dimethylhydantoin (DBH) and potassium iodide or iodine in the same solvent. Both reagents yield equivalent results by means of method comparison according to Passing and Bablok [J. Clin. Chem. Clin. Biochem. 21 (1983) 709; 22, (1984) 431] in relation to the official method of PH. EUR.

Publication types

  • Comparative Study

MeSH terms

  • Hydantoins / analysis*
  • Hydantoins / chemical synthesis
  • Hydantoins / standards
  • Iodine / analysis*
  • Iodine / chemistry
  • Iodine / standards
  • Pharmacopoeias as Topic* / standards

Substances

  • Hydantoins
  • Iodine
  • 1,3-dibromo-5,5-dimethylhydantoin