Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis

Arthritis Res. 2002;4(1):71-6. doi: 10.1186/ar386. Epub 2001 Oct 16.

Abstract

Circulating CD8(+) CD28(-) T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 +/- 17.7% versus 18.6 +/- 7.6%). The level of CD8(+)CD28(-) T cells was dependent on the disease status, but was independent of age. Most of the CD8(+) CD28(-) T cells produced perforin after stimulation in vitro, in contrast to their CD8(+)CD28(+) counterparts. From the clinical perspective, the percentage of the cytotoxic CD8(+) CD28(-) T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P = 0.032).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD28 Antigens / blood*
  • Cytomegalovirus / immunology
  • Cytomegalovirus / isolation & purification
  • Female
  • Flow Cytometry
  • Herpesvirus 4, Human / immunology
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Interferon-gamma / metabolism
  • Male
  • Membrane Glycoproteins / metabolism
  • Middle Aged
  • Perforin
  • Pore Forming Cytotoxic Proteins
  • Single-Blind Method
  • Spondylitis, Ankylosing / immunology*
  • Spondylitis, Ankylosing / metabolism
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / metabolism
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism

Substances

  • CD28 Antigens
  • Membrane Glycoproteins
  • Pore Forming Cytotoxic Proteins
  • Perforin
  • Interferon-gamma