Abstract
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.
MeSH terms
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Actins / metabolism*
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Alkyl and Aryl Transferases / antagonists & inhibitors
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Alkyl and Aryl Transferases / physiology
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Animals
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Antineoplastic Agents / pharmacology
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Apoptosis / physiology*
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Cell Adhesion / physiology
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Cell Division / physiology
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DNA Damage
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Enzyme Induction
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Enzyme Inhibitors / pharmacology
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Farnesyltranstransferase
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Guanosine Triphosphate / metabolism
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Humans
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Mice
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Multigene Family
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Neoplasm Proteins / antagonists & inhibitors
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Neoplasm Proteins / physiology
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / pathology
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Paclitaxel / pharmacology
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Protein Prenylation / drug effects
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Protein Processing, Post-Translational / drug effects
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Signal Transduction / physiology
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Stress, Physiological / genetics
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Stress, Physiological / metabolism
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ras Proteins / antagonists & inhibitors
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rhoB GTP-Binding Protein / physiology*
Substances
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Actins
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Antineoplastic Agents
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Enzyme Inhibitors
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Neoplasm Proteins
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Guanosine Triphosphate
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Alkyl and Aryl Transferases
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geranylgeranyltransferase type-I
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Farnesyltranstransferase
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ras Proteins
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rhoB GTP-Binding Protein
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Paclitaxel