Actin' up: RhoB in cancer and apoptosis

Nat Rev Cancer. 2001 Nov;1(2):162-8. doi: 10.1038/35101096.

Abstract

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

Publication types

  • Review

MeSH terms

  • Actins / metabolism*
  • Alkyl and Aryl Transferases / antagonists & inhibitors
  • Alkyl and Aryl Transferases / physiology
  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis / physiology*
  • Cell Adhesion / physiology
  • Cell Division / physiology
  • DNA Damage
  • Enzyme Induction
  • Enzyme Inhibitors / pharmacology
  • Farnesyltranstransferase
  • Guanosine Triphosphate / metabolism
  • Humans
  • Mice
  • Multigene Family
  • Neoplasm Proteins / antagonists & inhibitors
  • Neoplasm Proteins / physiology
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Paclitaxel / pharmacology
  • Protein Prenylation / drug effects
  • Protein Processing, Post-Translational / drug effects
  • Signal Transduction / physiology
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism
  • ras Proteins / antagonists & inhibitors
  • rhoB GTP-Binding Protein / physiology*

Substances

  • Actins
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Neoplasm Proteins
  • Guanosine Triphosphate
  • Alkyl and Aryl Transferases
  • geranylgeranyltransferase type-I
  • Farnesyltranstransferase
  • ras Proteins
  • rhoB GTP-Binding Protein
  • Paclitaxel