Abstract
Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.
MeSH terms
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Anaphase / physiology
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Cell Cycle Proteins / metabolism*
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Fungal Proteins
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GTP-Binding Proteins / metabolism
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Mitosis*
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Nuclear Proteins
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases
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Protein Tyrosine Phosphatases*
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Saccharomyces cerevisiae Proteins*
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Signal Transduction
Substances
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CDC14 protein, S cerevisiae
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CDC15 protein
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Cell Cycle Proteins
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Fungal Proteins
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Nuclear Proteins
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SPO12 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Protein Kinases
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Protein Serine-Threonine Kinases
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CDC5 protein, S cerevisiae
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Protein Tyrosine Phosphatases
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GTP-Binding Proteins