Aseptic meningitis associated with rofecoxib

Renan A Bonnel; Maria L Villalba; Claudia B Karwoski; Julie Beitz

doi:10.1001/archinte.162.6.713

Aseptic meningitis associated with rofecoxib

Arch Intern Med. 2002 Mar 25;162(6):713-5. doi: 10.1001/archinte.162.6.713.

Authors

Renan A Bonnel¹, Maria L Villalba, Claudia B Karwoski, Julie Beitz

Affiliation

¹ Office of Postmarketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Ln, Room 15B-23, HFD-430, Rockville, MD 20857, USA. bonnelr@cder.fda.gov

PMID: 11911727
DOI: 10.1001/archinte.162.6.713

Abstract

Rofecoxib is a nonsteroidal anti-inflammatory drug that is reported to act by selectively inhibiting cyclooxygenase-2. A review and analysis of reports sent to the Spontaneous Reporting System of the Food and Drug Administration, Rockville, Md, suggest that aseptic meningitis is associated with rofecoxib use. To our knowledge, there have been no published reports of aseptic meningitis occurring in association with rofecoxib use to date. We report 5 serious cases of aseptic meningitis associated with rofecoxib use.

Publication types

Case Reports

MeSH terms

Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Arthritis, Rheumatoid / drug therapy
Carpal Tunnel Syndrome / drug therapy
Female
Humans
Lactones / adverse effects*
Lactones / therapeutic use
Male
Meningitis, Aseptic / chemically induced*
Meningitis, Aseptic / diagnosis
Middle Aged
Neck Pain / drug therapy
Osteoarthritis / drug therapy
Pain, Postoperative / drug therapy
Sulfones

Substances

Anti-Inflammatory Agents, Non-Steroidal
Lactones
Sulfones
rofecoxib