Stimulatory and inhibitory effects of 5-HT(1A) receptors on adrenocorticotropic hormone and cortisol secretion in a teleost fish, the Arctic charr (Salvelinus alpinus)

Neurosci Lett. 2002 May 24;324(3):193-6. doi: 10.1016/s0304-3940(02)00200-8.

Abstract

The serotonin(1A) (5-HT(1A)) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) was administrated to juvenile Arctic charr either by intraperitoneal (i.p.) injections or through a permanent i.p. implanted catheter. 8-OH-DPAT induced an elevation of plasma cortisol in non-stressed fish (receiving the drug through a permanent i.p. catheter), whereas 8-OH-DPAT had the opposite effect when administrated through a standard i.p. injection, dampening the rise in cortisol induced by handling and injection, an effect which was most pronounced at low doses of 8-OH-DPAT. In both cases, plasma levels of adrenocorticotropic hormone followed the same general pattern as plasma cortisol. The results suggests that 5-HT(1A) receptors are involved in the regulation of hypothalamic-pituitary-interrenal axis activity in Arctic charr, but the effect of 5-HT(1A) stimulation seems to vary depending on the state of the fish.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
  • Adrenocorticotropic Hormone / blood*
  • Adrenocorticotropic Hormone / metabolism
  • Animals
  • Hydrocortisone / blood*
  • Hydrocortisone / metabolism
  • Hypothalamo-Hypophyseal System / drug effects
  • Hypothalamo-Hypophyseal System / metabolism*
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology
  • Neural Pathways / drug effects
  • Neural Pathways / physiology
  • Neurons / drug effects
  • Neurons / metabolism*
  • Pituitary-Adrenal System / drug effects
  • Pituitary-Adrenal System / metabolism*
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / metabolism*
  • Receptors, Serotonin, 5-HT1
  • Serotonin / metabolism*
  • Serotonin Receptor Agonists / pharmacology
  • Stress, Physiological / blood
  • Stress, Physiological / physiopathology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Trout / anatomy & histology
  • Trout / metabolism*

Substances

  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Receptor Agonists
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Adrenocorticotropic Hormone
  • Hydrocortisone