Abstract
The serotonin(1A) (5-HT(1A)) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) was administrated to juvenile Arctic charr either by intraperitoneal (i.p.) injections or through a permanent i.p. implanted catheter. 8-OH-DPAT induced an elevation of plasma cortisol in non-stressed fish (receiving the drug through a permanent i.p. catheter), whereas 8-OH-DPAT had the opposite effect when administrated through a standard i.p. injection, dampening the rise in cortisol induced by handling and injection, an effect which was most pronounced at low doses of 8-OH-DPAT. In both cases, plasma levels of adrenocorticotropic hormone followed the same general pattern as plasma cortisol. The results suggests that 5-HT(1A) receptors are involved in the regulation of hypothalamic-pituitary-interrenal axis activity in Arctic charr, but the effect of 5-HT(1A) stimulation seems to vary depending on the state of the fish.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
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Adrenocorticotropic Hormone / blood*
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Adrenocorticotropic Hormone / metabolism
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Animals
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Hydrocortisone / blood*
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Hydrocortisone / metabolism
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / metabolism*
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Neural Inhibition / drug effects
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Neural Inhibition / physiology
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Neural Pathways / drug effects
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Neural Pathways / physiology
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Neurons / drug effects
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Neurons / metabolism*
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / metabolism*
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT1
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Serotonin / metabolism*
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Serotonin Receptor Agonists / pharmacology
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Stress, Physiological / blood
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Stress, Physiological / physiopathology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Trout / anatomy & histology
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Trout / metabolism*
Substances
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Receptor Agonists
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Serotonin
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Adrenocorticotropic Hormone
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Hydrocortisone