Abstract
Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkynes / chemical synthesis
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Alkynes / chemistry*
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Catalysis
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Copper / chemistry*
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Imines / chemical synthesis
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Imines / chemistry*
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Organometallic Compounds / chemistry
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Pargyline / analogs & derivatives*
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Pargyline / chemical synthesis*
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Propylamines / chemical synthesis*
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Stereoisomerism
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Toluene / chemistry
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Water / chemistry
Substances
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Alkynes
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Imines
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Organometallic Compounds
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Propylamines
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Water
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propargylamine
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Toluene
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Copper
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Pargyline