Abstract
Recent studies have identified the inositol polyphosphate 5-phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene-targeted deletion of 5-phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.
MeSH terms
-
Animals
-
Calcium Signaling
-
Gene Targeting
-
Hematopoietic Stem Cells / cytology
-
Hematopoietic Stem Cells / physiology
-
Humans
-
Inositol 1,4,5-Trisphosphate / metabolism
-
Inositol Phosphates / metabolism
-
Inositol Polyphosphate 5-Phosphatases
-
Insulin / metabolism
-
Models, Biological
-
Oculocerebrorenal Syndrome / enzymology
-
Oculocerebrorenal Syndrome / genetics
-
Phosphoric Monoester Hydrolases / genetics
-
Phosphoric Monoester Hydrolases / metabolism*
-
Saccharomyces cerevisiae / enzymology
-
Saccharomyces cerevisiae / genetics
-
Signal Transduction
-
Synaptic Vesicles / metabolism
Substances
-
Inositol Phosphates
-
Insulin
-
inositol-1,3,4,5-tetrakisphosphate
-
Inositol 1,4,5-Trisphosphate
-
Phosphoric Monoester Hydrolases
-
Inositol Polyphosphate 5-Phosphatases