An EVH1/WH1 domain as a key actor in TGFbeta signalling

FEBS Lett. 2002 May 22;519(1-3):178-80. doi: 10.1016/s0014-5793(02)02751-5.

Abstract

EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands. An EVH1/WH1 domain is here identified in the recently cloned SMIF protein, a key protein in transforming growth factor-beta (TGFbeta) signalling which was not yet related to defined domains. The SMIF EVH1/WH1 domain interacts with the proline-rich Smad4 activation domain, leading to translocation of so-formed complex to the nucleus where SMIF possesses strong intrinsic TGFbeta-inducible transcriptional activity. This finding highlights the pivotal role that the EVH1/WH1 family of domains play in multiple eukaryotic signal transduction pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Factors / genetics
  • Biological Factors / physiology*
  • Cell Adhesion Molecules / genetics
  • Cluster Analysis
  • Computational Biology
  • Conserved Sequence
  • Drosophila melanogaster
  • Humans
  • Ligands
  • Mice
  • Microfilament Proteins
  • Models, Molecular
  • Molecular Sequence Data
  • Phosphoproteins / genetics
  • Protein Binding
  • Protein Structure, Tertiary / physiology
  • Proteins / genetics
  • Rats
  • Saccharomyces cerevisiae
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / physiology*
  • Wiskott-Aldrich Syndrome Protein

Substances

  • Biological Factors
  • Cell Adhesion Molecules
  • Ligands
  • Microfilament Proteins
  • Phosphoproteins
  • Proteins
  • Transforming Growth Factor beta
  • WAS protein, human
  • Was protein, mouse
  • Was protein, rat
  • Wiskott-Aldrich Syndrome Protein
  • vasodilator-stimulated phosphoprotein
  • smooth muscle inhibitory factor