Abstract
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
MeSH terms
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3-Phosphoinositide-Dependent Protein Kinases
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Animals
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Cell Membrane / metabolism
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Cell Physiological Phenomena
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism
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Humans
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Models, Biological
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphatidylinositol 4,5-Diphosphate / metabolism
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Phosphatidylinositol Phosphates / chemistry
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Phosphatidylinositol Phosphates / metabolism*
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Phosphorylation
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-akt
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Signal Transduction*
Substances
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Phosphatidylinositol 4,5-Diphosphate
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Phosphatidylinositol Phosphates
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Proto-Oncogene Proteins
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phosphatidylinositol 3,4,5-triphosphate
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Protein Kinases
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3-Phosphoinositide-Dependent Protein Kinases
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt