Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

J Neuroimmunol. 2002 Jun;127(1-2):59-68. doi: 10.1016/s0165-5728(02)00097-8.

Abstract

T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Astrocytes / chemistry
  • Astrocytes / immunology
  • CD4-Positive T-Lymphocytes / chemistry
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / chemistry
  • CD8-Positive T-Lymphocytes / immunology
  • Central Nervous System / chemistry*
  • Central Nervous System / immunology*
  • Central Nervous System / pathology
  • Cerebrospinal Fluid / cytology
  • Chemokine CXCL10
  • Chemokines, CXC / analysis*
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / pathology
  • Myelitis, Transverse / immunology
  • Myelitis, Transverse / pathology
  • Optic Neuritis / immunology
  • Optic Neuritis / pathology
  • Receptors, CXCR3
  • Receptors, Chemokine / analysis*

Substances

  • CXCR3 protein, human
  • Chemokine CXCL10
  • Chemokines, CXC
  • Receptors, CXCR3
  • Receptors, Chemokine