Abstract
ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Surface / chemistry
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Antigens, Surface / genetics
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Antigens, Surface / metabolism*
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Humans
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Immunity, Innate*
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Lipid Metabolism*
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Lipopolysaccharides / immunology
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Lipopolysaccharides / metabolism
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Molecular Sequence Data
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Protein Structure, Tertiary
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Sequence Alignment
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Signal Transduction / physiology
Substances
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Antigens, Surface
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LY86 protein, human
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Lipopolysaccharides