Abstract
It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.
MeSH terms
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Animals
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Animals, Newborn
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Cnidaria
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Coleoptera
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Gene Expression Regulation*
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Gene Transfer Techniques*
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Green Fluorescent Proteins
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Liver / metabolism
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Luciferases / genetics
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Luminescent Proteins / genetics
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Mice
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Plasmids
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RNA, Small Interfering
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RNA, Untranslated / administration & dosage*
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Transgenes
Substances
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Luminescent Proteins
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RNA, Small Interfering
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RNA, Untranslated
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Green Fluorescent Proteins
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Luciferases