Abstract
Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.
MeSH terms
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Animals
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DNA-Binding Proteins / metabolism*
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E2F4 Transcription Factor
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Gene Expression Regulation / drug effects*
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Macromolecular Substances
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Models, Biological
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Nuclear Proteins / metabolism*
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Proto-Oncogene Proteins c-myc / metabolism*
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Signal Transduction / drug effects
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Smad3 Protein
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Trans-Activators / metabolism*
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Transcription Factors / metabolism*
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Transforming Growth Factor beta / pharmacology*
Substances
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DNA-Binding Proteins
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E2F4 Transcription Factor
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Macromolecular Substances
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Nuclear Proteins
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Proto-Oncogene Proteins c-myc
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Smad3 Protein
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Trans-Activators
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Transcription Factors
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Transforming Growth Factor beta