Abstract
The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Algorithms
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Computer-Aided Design
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Databases, Protein*
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Energy Metabolism*
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Entropy
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Models, Chemical
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Models, Molecular
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Models, Statistical
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Protein Conformation*
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Protein Engineering / methods*
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Proteins / chemistry*
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Proteins / genetics
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Sequence Analysis, Protein
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Static Electricity
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Structure-Activity Relationship
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Thermodynamics*