Energy estimation in protein design

Curr Opin Struct Biol. 2002 Aug;12(4):441-6. doi: 10.1016/s0959-440x(02)00345-7.

Abstract

The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Computer-Aided Design
  • Databases, Protein*
  • Energy Metabolism*
  • Entropy
  • Models, Chemical
  • Models, Molecular
  • Models, Statistical
  • Protein Conformation*
  • Protein Engineering / methods*
  • Proteins / chemistry*
  • Proteins / genetics
  • Sequence Analysis, Protein
  • Static Electricity
  • Structure-Activity Relationship
  • Thermodynamics*

Substances

  • Proteins