A simple and advantageous protocol for the oxidation of alcohols with O-iodoxybenzoic acid (IBX)

Org Lett. 2002 Aug 22;4(17):3001-3. doi: 10.1021/ol026427n.

Abstract

[reaction: see text] An efficient, user-friendly procedure for the oxidation of alcohols using IBX is described. Simply heating a solution of the alcohol in the presence of suspended IBX followed by filtration and removal of the solvent gives excellent yields of the corresponding carbonyl compounds. We illustrate this procedure with a panel of primary and secondary alcohol substrates and note that it allows recycling and reuse of the oxidant.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohols / chemistry
  • Environmental Pollution / prevention & control
  • Equipment Reuse
  • Iodobenzenes
  • Iodobenzoates / chemistry*
  • Ketones / chemical synthesis*
  • Oxidants / chemistry
  • Oxidation-Reduction
  • Solvents

Substances

  • Alcohols
  • Iodobenzenes
  • Iodobenzoates
  • Ketones
  • Oxidants
  • Solvents
  • o-iodoxybenzoic acid