Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts

Akira Andoh; Mitsue Shimada; Shigeki Bamba; Takafumi Okuno; Yoshio Araki; Yoshihide Fujiyama; Tadao Bamba

doi:10.1016/s0167-4889(02)00250-1

Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts

Biochim Biophys Acta. 2002 Aug 19;1591(1-3):69-74. doi: 10.1016/s0167-4889(02)00250-1.

Authors

Akira Andoh¹, Mitsue Shimada, Shigeki Bamba, Takafumi Okuno, Yoshio Araki, Yoshihide Fujiyama, Tadao Bamba

Affiliation

¹ Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan. andoh@belle.shiga-med.ac.jp

PMID: 12183057
DOI: 10.1016/s0167-4889(02)00250-1

Abstract

In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha-induced IL-6 secretion through the induction of IL-6 mRNA stabilization. Induced stability of IL-6 mRNA was markedly decreased by the inhibitors of extracellular signal-regulated kinase (ERKs), PD98059 and U0216. This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Fibroblasts / metabolism
Fibroblasts / physiology
Humans
Interleukin-17 / metabolism*
Interleukin-6 / genetics
Interleukin-6 / metabolism*
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases / metabolism*
Pancreas / cytology
RNA Stability
RNA, Messenger / metabolism
Tumor Necrosis Factor-alpha / metabolism*

Substances

Interleukin-17
Interleukin-6
RNA, Messenger
Tumor Necrosis Factor-alpha
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases