Abstract
The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the alpha subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal.
Copyright 2002 S. Karger AG, Basel
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA-Binding Proteins / metabolism
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Erythropoietin / physiology*
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Gene Expression Regulation
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Humans
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Hypoxia / metabolism
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Ligases / metabolism
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Mixed Function Oxygenases
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Nuclear Proteins / metabolism
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Oxygen / physiology*
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Procollagen-Proline Dioxygenase / metabolism
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Repressor Proteins / metabolism
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Signal Transduction
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Transcription Factors / metabolism
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Tumor Suppressor Proteins*
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Ubiquitin-Protein Ligases*
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Von Hippel-Lindau Tumor Suppressor Protein
Substances
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DNA-Binding Proteins
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HIF1A protein, human
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Repressor Proteins
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Transcription Factors
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Tumor Suppressor Proteins
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Erythropoietin
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Mixed Function Oxygenases
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HIF1AN protein, human
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Procollagen-Proline Dioxygenase
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Ubiquitin-Protein Ligases
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Von Hippel-Lindau Tumor Suppressor Protein
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Ligases
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VHL protein, human
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Oxygen