Non-stop decay--a new mRNA surveillance pathway

Bioessays. 2002 Sep;24(9):785-8. doi: 10.1002/bies.10153.

Abstract

Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several surveillance mechanisms have evolved to check the fidelity at each step of mRNA manufacture. Two recent reports describe the identification of a novel pathway in eukaryotes that recognizes and degrades mRNAs that lack a stop codon. The non-stop decay mechanism releases ribosomes stalled at the 3' end of a mRNA and stimulates the exosome to rapidly degrade the transcript.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 3' Untranslated Regions
  • Adaptor Proteins, Signal Transducing
  • Binding Sites
  • Cell Nucleus / metabolism
  • Codon, Terminator
  • Cytoplasm / metabolism
  • Fungal Proteins / metabolism
  • GTP-Binding Proteins*
  • Models, Biological
  • Protein Binding
  • RNA, Messenger / metabolism*
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*

Substances

  • 3' Untranslated Regions
  • Adaptor Proteins, Signal Transducing
  • Codon, Terminator
  • Fungal Proteins
  • RNA, Messenger
  • SKI7 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • GTP-Binding Proteins