Abstract
A potent benzodiazepin derivative, clonazepam, was studied over a range of single doses to determine tolerance for the drug. The best tolerated doses were 0.5 and 1 mg. Higher doses were associated with considerable evidence of sedation, more easily detected by clinical questioning and observation than by commonly used self-reporting scales or motor tests.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Benzodiazepinones / pharmacology*
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Clonazepam / administration & dosage
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Clonazepam / adverse effects
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Clonazepam / pharmacology*
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Emotions / drug effects
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Humans
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Male
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Middle Aged
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Motor Skills / drug effects
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Reaction Time / drug effects
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Sleep / drug effects
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Time Factors
Substances
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Benzodiazepinones
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Clonazepam