PIP: The results of 2 studies on the use of high doses of progestins as postcoitum contraceptives are reported. 1 of the studies was carried out in Peru and involved 4632 women, treated for 41,802 months with single doses of 150, 250, 300, 350, and 400 mcg of D-Norgestrel, administered within 3 hours postcoitum (the doses were administered to 28, 699, 544, 559, and 2801 women, respectively). 165 unwanted pregnancies were reported; their incidence was higher among women treated with the smaller doses. The most important side effects were changes in the duration of the cycle; spotting was present in 10% of the cases and independent of the dose; liver disorders, thromboembolic accidents and breast pains were absent; treatment had to be suspended because of side effects in 5-8% of the cases. The 2nd study was carried out in Chile and involved 136 fertile women for 184 months, treated with 3 different progestins. A total of 5 pregnancies were reported and the treatment was well tolerated by all patients. Generally, it is concluded that these 1st studies suggest that high doses of progestins are effective and well tolerated postcoitum contraceptives, and side effects are less frequent and serious than those produced by estrogen preparations.