Characterization of human stellate cell activation-associated protein and its expression in human liver

Biochim Biophys Acta. 2002 Sep 27;1577(3):471-5. doi: 10.1016/s0167-4781(02)00477-3.

Abstract

This study cloned cDNA of human homologue (hSTAP) of rat stellate cell activation-associated protein (rSTAP). hSTAP gene is on chromosome 17q and is composed of four exons. Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chromosomes, Human, Pair 17
  • Cytoglobin
  • DNA, Complementary / biosynthesis
  • DNA, Complementary / chemistry
  • Exons
  • Globins
  • Hemeproteins / genetics*
  • Hepatitis, Autoimmune / metabolism
  • Hepatitis, Viral, Human / metabolism
  • Humans
  • Immunohistochemistry
  • Liver / metabolism*
  • Molecular Sequence Data
  • Peroxidases / biosynthesis
  • Peroxidases / chemistry
  • Peroxidases / genetics*
  • Recombinant Proteins / chemistry
  • Sequence Alignment

Substances

  • Cytoglobin
  • DNA, Complementary
  • Hemeproteins
  • Recombinant Proteins
  • Globins
  • Peroxidases