A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

Xu Wu; Sheng Ding; Qiang Ding; Nathanael S Gray; Peter G Schultz

doi:10.1021/ja0283908

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

J Am Chem Soc. 2002 Dec 11;124(49):14520-1. doi: 10.1021/ja0283908.

Authors

Xu Wu¹, Sheng Ding, Qiang Ding, Nathanael S Gray, Peter G Schultz

Affiliation

¹ Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

PMID: 12465946
DOI: 10.1021/ja0283908

Abstract

Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaline Phosphatase / biosynthesis
Animals
Cell Differentiation / drug effects
Combinatorial Chemistry Techniques
Mesoderm / cytology
Mesoderm / drug effects
Mesoderm / enzymology
Mice
Mice, Inbred C3H
Morpholines / pharmacology*
Osteoblasts / cytology
Osteoblasts / drug effects
Osteoblasts / enzymology
Osteogenesis / drug effects*
Purines / pharmacology*
Stem Cells / cytology
Stem Cells / drug effects*
Stem Cells / enzymology

Substances

Morpholines
Purines
Alkaline Phosphatase
purmorphamine