HL-A frequencies in Down's syndrome

Humangenetik. 1975;27(1):45-8. doi: 10.1007/BF00283502.

Abstract

HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Child
  • Cytotoxicity Tests, Immunologic
  • Down Syndrome / immunology*
  • Gene Frequency*
  • HLA Antigens*
  • Histocompatibility Antigens*
  • Humans
  • Middle Aged

Substances

  • HLA Antigens
  • Histocompatibility Antigens