Abstract
Buprenorphine, a long-acting opioid with both agonist and antagonist properties, binds to mu-opioid (OP(3)), kappa-opioid (OP(2)), delta-opioid (OP(1)), and nociceptin (ORL-1) receptors. Its actions at these receptors have not been completely characterized, although buprenorphine is generally regarded as a mu-opioid receptor partial agonist and a kappa-opioid receptor antagonist. Its pharmacology is further complicated by an active metabolite, norbuprenorphine. Although buprenorphine can be used as an analgesic agent, it is of greater importance in the treatment of opioid abuse. Because of its partial agonist activity at mu-opioid receptors and its long half-life, buprenorphine has proven to be an excellent alternative to methadone for either maintenance therapy or detoxification of the opioid addict. Although buprenorphine may ultimately prove to be superior to methadone in the maintenance of the pregnant addict, its effects on the developing fetus must be carefully evaluated.
MeSH terms
-
Analgesics, Opioid / adverse effects
-
Analgesics, Opioid / pharmacology
-
Analgesics, Opioid / therapeutic use*
-
Animals
-
Buprenorphine / adverse effects
-
Buprenorphine / pharmacology
-
Buprenorphine / therapeutic use*
-
Female
-
Humans
-
Infant, Newborn
-
Narcotic Antagonists / adverse effects
-
Narcotic Antagonists / pharmacology
-
Narcotic Antagonists / therapeutic use*
-
Neonatal Abstinence Syndrome / etiology
-
Opioid-Related Disorders / complications
-
Opioid-Related Disorders / drug therapy*
-
Opioid-Related Disorders / rehabilitation
-
Pregnancy
-
Pregnancy Complications / drug therapy
-
Pregnancy Complications / rehabilitation
-
Receptors, Opioid / drug effects*
-
Receptors, Opioid / metabolism
-
Receptors, Opioid, delta / drug effects
-
Receptors, Opioid, delta / metabolism
-
Receptors, Opioid, kappa / drug effects
-
Receptors, Opioid, kappa / metabolism
-
Receptors, Opioid, mu / drug effects
-
Receptors, Opioid, mu / metabolism
Substances
-
Analgesics, Opioid
-
Narcotic Antagonists
-
Receptors, Opioid
-
Receptors, Opioid, delta
-
Receptors, Opioid, kappa
-
Receptors, Opioid, mu
-
Buprenorphine