Abstract
Chronic myelocytic leukemia (CML) is a chronic myeloproliferative disorder characterized by cytogenetic or molecular evidence of Philadelphia (Ph) chromosome, t(9;22)(q34;q11). Mild to moderate eosinophilia is commonly seen in CML. However, eosinophilia as a dominant feature of CML is extremely rare. We describe a case of Ph(-) CML with eosinophilia. Loeffler endocarditis, and t(9;12)(q34;p13) that resulted in an ETV6-ABL gene rearrangement/fusion identified to the best of our knowledge, for the first time by using commercially available fluorescence in situ hybridization probes.
MeSH terms
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Adult
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Aged
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Chromosomes, Human, Pair 12 / genetics*
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Chromosomes, Human, Pair 9 / genetics*
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Eosinophilia / complications*
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Eosinophilia / genetics*
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Female
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Fusion Proteins, bcr-abl / genetics
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Humans
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In Situ Hybridization, Fluorescence
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Male
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Middle Aged
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Oncogene Proteins, Fusion / genetics*
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Philadelphia Chromosome
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Protein-Tyrosine Kinases
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Reverse Transcriptase Polymerase Chain Reaction
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Translocation, Genetic / genetics*
Substances
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Oncogene Proteins, Fusion
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TEL-ABL fusion protein, human
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Protein-Tyrosine Kinases
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Fusion Proteins, bcr-abl