Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature

Cancer Genet Cytogenet. 2002 Oct 15;138(2):139-42. doi: 10.1016/s0165-4608(02)00609-x.

Abstract

Chronic myelocytic leukemia (CML) is a chronic myeloproliferative disorder characterized by cytogenetic or molecular evidence of Philadelphia (Ph) chromosome, t(9;22)(q34;q11). Mild to moderate eosinophilia is commonly seen in CML. However, eosinophilia as a dominant feature of CML is extremely rare. We describe a case of Ph(-) CML with eosinophilia. Loeffler endocarditis, and t(9;12)(q34;p13) that resulted in an ETV6-ABL gene rearrangement/fusion identified to the best of our knowledge, for the first time by using commercially available fluorescence in situ hybridization probes.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Eosinophilia / complications*
  • Eosinophilia / genetics*
  • Female
  • Fusion Proteins, bcr-abl / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics*
  • Philadelphia Chromosome
  • Protein-Tyrosine Kinases
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic / genetics*

Substances

  • Oncogene Proteins, Fusion
  • TEL-ABL fusion protein, human
  • Protein-Tyrosine Kinases
  • Fusion Proteins, bcr-abl