Abstract
This study was designed to investigate the time lag of effect of NS398, selective COX-2 inhibitor, on infarct volume and neurologic deficits in mice with experimentally-induced cerebral ischemia. Our results showed that the beneficial effect of NS398 on reduction of infarct volume and improvement of neurologic deficits were noted more than 24 h after the injection regardless of the administration timing.
MeSH terms
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Acute Disease
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Animals
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Body Temperature / physiology
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Body Weight / physiology
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Brain Ischemia / enzymology*
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Brain Ischemia / physiopathology
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / pharmacology*
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Infarction, Middle Cerebral Artery / pathology
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Isoenzymes / metabolism*
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Male
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Mice
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Mice, Inbred C57BL
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Middle Cerebral Artery / physiology
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Nervous System Diseases / chemically induced
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Nervous System Diseases / pathology
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Nitrobenzenes / pharmacology*
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Sulfonamides / pharmacology*
Substances
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Nitrobenzenes
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Sulfonamides
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N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases