Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

Arch Pharm Res. 2002 Dec;25(6):817-9. doi: 10.1007/BF02976997.

Abstract

In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Animals
  • Brain / drug effects
  • Brain / enzymology
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / pharmacology*
  • Corydalis / chemistry*
  • Dose-Response Relationship, Drug
  • Mice
  • Plant Components, Aerial* / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*

Substances

  • Cholinesterase Inhibitors
  • Plant Extracts
  • Acetylcholinesterase