Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Jacqueline D Trudeau; Carolyn Kelly-Smith; C Bruce Verchere; John F Elliott; Jan P Dutz; Diane T Finegood; Pere Santamaria; Rusung Tan

doi:10.1172/JCI16409

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

J Clin Invest. 2003 Jan;111(2):217-23. doi: 10.1172/JCI16409.

Authors

Jacqueline D Trudeau¹, Carolyn Kelly-Smith, C Bruce Verchere, John F Elliott, Jan P Dutz, Diane T Finegood, Pere Santamaria, Rusung Tan

Affiliation

¹ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 12531877
PMCID: PMC151866
DOI: 10.1172/JCI16409

Abstract

Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.

Publication types

Comment
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
Diabetes Mellitus, Type 1 / diagnosis*
Diabetes Mellitus, Type 1 / immunology*
Epitopes, T-Lymphocyte
Female
Histocompatibility Antigens Class I / chemistry
Histocompatibility Antigens Class I / metabolism
Islets of Langerhans / immunology
Lymphocyte Count*
Mice
Mice, Inbred NOD

Substances

Epitopes, T-Lymphocyte
Histocompatibility Antigens Class I