Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex

Pharmazie. 2002 Dec;57(12):857-8.

Abstract

A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • Brain / metabolism
  • Dimethyl Sulfoxide
  • Flavonoids / chemical synthesis*
  • Flavonoids / pharmacology*
  • Flunitrazepam / pharmacokinetics
  • GABA Modulators / pharmacokinetics
  • Magnetic Resonance Spectroscopy
  • Plant Roots / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A / drug effects*
  • Receptors, GABA-A / metabolism*
  • Scutellaria / chemistry*

Substances

  • 5,7,2'-trihydroxy-6,8-dimethoxyflavone
  • 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone
  • Flavonoids
  • GABA Modulators
  • Receptors, GABA-A
  • Flunitrazepam
  • Dimethyl Sulfoxide