A fluorescent sensor with high selectivity and sensitivity for potassium in water

J Am Chem Soc. 2003 Feb 12;125(6):1468-9. doi: 10.1021/ja0284761.

Abstract

This communication describes a new optical sensor suitable for practical measurement of extracellular (serum or whole blood) potassium. The sensor responds rapidly and reversibly to changes in potassium concentrations typical of whole blood samples. No interferences from clinical concentrations of calcium or pH are observed, and the sodium interference is very minor. Excitation and emission occur in the visible light region. This new potassium sensor is currently used in the Roche OPTI CCA, a commercially available whole blood analyzer.

MeSH terms

  • 1-Naphthylamine / analogs & derivatives*
  • 1-Naphthylamine / chemistry
  • Biosensing Techniques / methods*
  • Ethers, Cyclic / chemistry
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Hydrogen-Ion Concentration
  • Ionophores / chemical synthesis
  • Ionophores / chemistry
  • Kinetics
  • Naphthalimides
  • Potassium / analysis*
  • Potassium / blood
  • Quinolones / chemistry
  • Sensitivity and Specificity
  • Solutions
  • Spectrometry, Fluorescence / methods
  • Water / chemistry

Substances

  • Ethers, Cyclic
  • Fluorescent Dyes
  • Ionophores
  • Naphthalimides
  • Quinolones
  • Solutions
  • Water
  • 4-amino-1,8-naphthalimide
  • 1-Naphthylamine
  • Potassium