Eukaryotic translation initiation factors and regulators

Curr Opin Struct Biol. 2003 Feb;13(1):56-63. doi: 10.1016/s0959-440x(03)00009-5.

Abstract

Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Eukaryotic Initiation Factor-2 / chemistry
  • Eukaryotic Initiation Factor-2 / metabolism
  • Eukaryotic Initiation Factor-4E / chemistry
  • Eukaryotic Initiation Factor-4E / metabolism
  • Eukaryotic Initiation Factor-4G / genetics
  • Eukaryotic Initiation Factor-4G / metabolism
  • Eukaryotic Initiation Factors / chemistry*
  • Eukaryotic Initiation Factors / metabolism
  • Gene Expression Regulation / physiology
  • Homeostasis / physiology
  • Macromolecular Substances
  • Models, Molecular*
  • Phosphorylation
  • Poly(A)-Binding Proteins / chemistry*
  • Poly(A)-Binding Proteins / metabolism
  • Protein Binding
  • Protein Biosynthesis / physiology
  • Protein Conformation
  • Protein Structure, Tertiary
  • RNA, Ribosomal / chemistry*
  • RNA, Transfer / chemistry*
  • RNA, Transfer / metabolism

Substances

  • Eukaryotic Initiation Factor-2
  • Eukaryotic Initiation Factor-4E
  • Eukaryotic Initiation Factor-4G
  • Eukaryotic Initiation Factors
  • Macromolecular Substances
  • Poly(A)-Binding Proteins
  • RNA, Ribosomal
  • RNA, Transfer