Abstract
Aqueous extract of Bauhinia megalandra leaves was able to inhibit the intestinal glucose absorption in a concentration-dependent way and additive to phlorizine. Moreover, B. megalandra leaf extract drastically reduced the 14C-glucose uptake by enterocyte brush border membrane vesicles. The B. megalandra leaf extract administrated orally, simultaneously with glucose improved the glucose tolerance with a significant reduction of the 30-min peak. The extract did not have an effect on the glucose tolerance when glucose was administrated subcutaneously.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Animals
-
Bauhinia*
-
Carbon Radioisotopes / metabolism
-
Diabetes Mellitus / prevention & control
-
Glucose / administration & dosage
-
Glucose / metabolism*
-
Glucose Tolerance Test
-
Hypoglycemic Agents / administration & dosage
-
Hypoglycemic Agents / pharmacology*
-
Hypoglycemic Agents / therapeutic use
-
Intestinal Absorption / drug effects*
-
Intestine, Small / drug effects
-
Intestine, Small / metabolism
-
Male
-
Microvilli / drug effects
-
Microvilli / metabolism
-
Phytotherapy*
-
Plant Extracts / administration & dosage
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
-
Plant Leaves
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Carbon Radioisotopes
-
Hypoglycemic Agents
-
Plant Extracts
-
Glucose