Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis

J Org Chem. 2003 Apr 4;68(7):2765-70. doi: 10.1021/jo0267910.

Abstract

Five new alkaloids, dictyodendrins A-E (1-5), were isolated from the Japanese marine sponge Dictyodendrilla verongiformis as telomerase inhibitors. Their structures were elucidated by spectroscopic and chemical methods. Dictyodendrins are tyramine-based pyrrolocarbazole derivatives containing three or four p-hydroxybenzene groups. They inhibited telomerase completely at a concentration of 50 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Carbazoles / chemistry
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Hydrolysis
  • Japan
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Pyrroles / chemistry
  • Stereoisomerism
  • Telomerase / antagonists & inhibitors*
  • Tyramine / chemistry

Substances

  • Alkaloids
  • Carbazoles
  • Enzyme Inhibitors
  • Pyrroles
  • Telomerase
  • Tyramine