The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6104-8. doi: 10.1073/pnas.1031527100. Epub 2003 Apr 28.

Abstract

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carbohydrates / pharmacology
  • Hepacivirus*
  • Imines / pharmacology*
  • Ion Channels / antagonists & inhibitors
  • Ion Channels / drug effects
  • Ion Channels / physiology*
  • Lipid Bilayers
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Molecular Sequence Data
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Viral Proteins / chemistry
  • Viral Proteins / physiology*

Substances

  • Carbohydrates
  • Imines
  • Ion Channels
  • Lipid Bilayers
  • Peptides
  • Viral Proteins
  • p7 protein, Hepatitis C virus