mRNA decay: x (XRN1) marks the spot

Mol Cell. 2003 May;11(5):1126-8. doi: 10.1016/s1097-2765(03)00198-9.

Abstract

Degradation of mRNA is a vital aspect of gene expression. In yeast, Dcp1p, Dcp2p, Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoplasm / genetics
  • Cytoplasm / metabolism*
  • Endoribonucleases / genetics
  • Endoribonucleases / metabolism
  • Eukaryotic Cells / metabolism*
  • Exoribonucleases / genetics
  • Exoribonucleases / metabolism*
  • Humans
  • RNA Cap-Binding Proteins
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Yeasts / genetics*
  • Yeasts / metabolism

Substances

  • LSM1 protein, S cerevisiae
  • RNA Cap-Binding Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Saccharomyces cerevisiae Proteins
  • DCP1 protein, S cerevisiae
  • DCP2 protein, S cerevisiae
  • Endoribonucleases
  • Exoribonucleases
  • XRN1 protein, S cerevisiae