Abstract
It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.
MeSH terms
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Animals
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Aurora Kinases
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Centrioles / chemistry
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Centrioles / physiology
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Centrioles / ultrastructure
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Centrosome / enzymology
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Centrosome / physiology*
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Drosophila Proteins*
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Dyneins / metabolism
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Humans
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Microtubule-Associated Proteins / metabolism
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Microtubules / metabolism
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Mitosis*
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Models, Biological
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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Tubulin / physiology
Substances
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Drosophila Proteins
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Microtubule-Associated Proteins
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Tubulin
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Aurora Kinases
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Protein Serine-Threonine Kinases
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Dyneins